Ph D in Medicinal Chemistry, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (2014)
BS in Traditional Chinese Medicine, Tongji Medical School, Huazhong University of Science and Technology (2009)
Publications
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of <i>N</i>′-Nitrosonornicotine (NNN) in the Rat Chemical Research in Toxicology 36 5 (2023),
Yupeng Li, Romel P. Dator, Laura A. Maertens, Silvia Balbo, Stephen S. Hecht.
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers Journal of Medicinal Chemistry 66 6 (2023),
Zehui Zhou, Guizhen Zhou, Chuan Zhou, Zisheng Fan, Rongrong Cui, Yupeng Li, Rui Li, Yuejiao Gu, Huajie Li, Zhiming Ge, Xiaojia Cai, Bing Jiang, Dan Wang, Mingyue Zheng, Tianfeng Xu, Sulin Zhang.
Design, Synthesis, and Bioevaluation of Pyrido[2,3-<i>d</i>]pyrimidin-7-ones as Potent SOS1 Inhibitors ACS Medicinal Chemistry Letters 14 2 (2023),
Meiying Liu, Guizhen Zhou, Wenhong Su, Yuejiao Gu, Mingshan Gao, Kun Wang, Ruifeng Huo, Yupeng Li, Zehui Zhou, Kaixian Chen, Mingyue Zheng, Sulin Zhang, Tianfeng Xu.
Mass Spectrometric Quantitation of <i>N</i>′-Nitrosonornicotine-1<i>N</i>-oxide in the Urine of Cigarette Smokers and Smokeless Tobacco Users Chemical Research in Toxicology 35 9 (2022),
Yupeng Li, Stephen S. Hecht.
Carcinogenic components of tobacco and tobacco smoke: A 2022 update Food and Chemical Toxicology 165 (2022),
Yupeng Li, Stephen S. Hecht.
Recent Developments in the Synthesis of Indole‐Pyrazole Hybrids ChemistrySelect 7 21 (2022),
K. Fabitha, Munugala Chandrakanth, Rakendu N. Pramod, C. G. Arya, Yupeng Li, Janardhan Banothu.
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations Journal of Medicinal Chemistry 65 5 (2022),
Chuan Zhou, Zisheng Fan, Zehui Zhou, Yupeng Li, Rongrong Cui, Chaoyi Liu, Guizhen Zhou, Xingxing Diao, Hualiang Jiang, Mingyue Zheng, Sulin Zhang, Tianfeng Xu.
Coumarin–benzimidazole hybrids: A review of developments in medicinal chemistry European Journal of Medicinal Chemistry 227 (2022),
Arya C. G, Ramesh Gondru, Yupeng Li, Janardhan Banothu.
Identification of an <i>N′</i>-Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA Chemical Research in Toxicology 34 4 (2021),
Yupeng Li, Stephen S. Hecht.
Investigation of 2′-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by <i>N</i>′-Nitrosonornicotine Metabolism Chemical Research in Toxicology 34 4 (2021),
Yupeng Li, Erik S. Carlson, Adam T. Zarth, Pramod Upadhyaya, Stephen S. Hecht.
Design and Optimization of 3′-(Imidazo[1,2-<i>a</i>]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors ACS Medicinal Chemistry Letters 11 3 (2020),
Cheng Mo, Zhang Zhang, Yupeng Li, Minhao Huang, Jian Zou, Jinfeng Luo, Zheng-Chao Tu, Yong Xu, Xiaomei Ren, Ke Ding, Xiaoyun Lu.
Resolution and Quantitation of Mercapturic Acids Derived from Crotonaldehyde, Methacrolein, and Methyl Vinyl Ketone in the Urine of Smokers and Nonsmokers Chemical Research in Toxicology 33 2 (2020),
Menglan Chen, Steven G. Carmella, Yupeng Li, Yingchun Zhao, Stephen S. Hecht.
Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with <i>N</i>′-Nitrosonornicotine Chemical Research in Toxicology 32 4 (2019),
Yupeng Li, Bin Ma, Qing Cao, Silvia Balbo, Lijiao Zhao, Pramod Upadhyaya, Stephen S. Hecht.
Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses Advanced Materials 30 45 (2018),
Lutz Nuhn, Stefaan De Koker, Sandra Van Lint, Zifu Zhong, João P. Catani, Francis Combes, Kim Deswarte, Yupeng Li, Bart N. Lambrecht, Stefan Lienenklaus, Niek N. Sanders, Sunil A. David, Jan Tavernier, Bruno G. De Geest.
Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles–TLR7/8 Agonist Conjugates Journal of the American Chemical Society 140 43 (2018),
Simon Van Herck, Kim Deswarte, Lutz Nuhn, Zifu Zhong, Joao P. Portela Catani, Yupeng Li, Niek N. Sanders, Stefan Lienenklaus, Stefaan De Koker, Bart N. Lambrecht, Sunil A. David, Bruno G. De Geest.
Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist. Biomaterials 178 (2018),
L Nuhn, L Van Hoecke, K Deswarte, B Schepens, Y Li , B N. Lambrecht, S De Koker, S A. David, X Saelens, B G. De Geest.
Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue. Bioconjugate chemistry 29 8 (2018),
E Yoo, Salyer ACD, Brush MJH, Y Li , K L. Trautman, N M. Shukla, A De Beuckelaer, S Lienenklaus, K Deswarte, B N. Lambrecht, B G. De Geest, S A. David.
Presentations
No info available.
Grants
No info available.
Current/Future Courses
Term
Course
Section
Syllabus
Fall 2023
PHAR 6219 - Principles of Drug Action IA
15432
Past Courses
No info available.
Course Evaluations
No info available.
Bio
No info available.
Ph D in Medicinal Chemistry, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (2014)
BS in Traditional Chinese Medicine, Tongji Medical School, Huazhong University of Science and Technology (2009)
Publications
Mass Spectrometry-Based Metabolic Profiling of Urinary Metabolites of <i>N</i>′-Nitrosonornicotine (NNN) in the Rat Chemical Research in Toxicology 36 5 (2023),
Yupeng Li, Romel P. Dator, Laura A. Maertens, Silvia Balbo, Stephen S. Hecht.
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers Journal of Medicinal Chemistry 66 6 (2023),
Zehui Zhou, Guizhen Zhou, Chuan Zhou, Zisheng Fan, Rongrong Cui, Yupeng Li, Rui Li, Yuejiao Gu, Huajie Li, Zhiming Ge, Xiaojia Cai, Bing Jiang, Dan Wang, Mingyue Zheng, Tianfeng Xu, Sulin Zhang.
Design, Synthesis, and Bioevaluation of Pyrido[2,3-<i>d</i>]pyrimidin-7-ones as Potent SOS1 Inhibitors ACS Medicinal Chemistry Letters 14 2 (2023),
Meiying Liu, Guizhen Zhou, Wenhong Su, Yuejiao Gu, Mingshan Gao, Kun Wang, Ruifeng Huo, Yupeng Li, Zehui Zhou, Kaixian Chen, Mingyue Zheng, Sulin Zhang, Tianfeng Xu.
Mass Spectrometric Quantitation of <i>N</i>′-Nitrosonornicotine-1<i>N</i>-oxide in the Urine of Cigarette Smokers and Smokeless Tobacco Users Chemical Research in Toxicology 35 9 (2022),
Yupeng Li, Stephen S. Hecht.
Carcinogenic components of tobacco and tobacco smoke: A 2022 update Food and Chemical Toxicology 165 (2022),
Yupeng Li, Stephen S. Hecht.
