Physical Therapist and rehabilitation scientist whose research expertise is pain mechanisms, especially central pain mechanisms, in knee osteoarthritis (OA) and chronic low back pain (CLBP)

• NIH All of Us Biomedical Researcher Scholars Award - Baylor College of Medicine (03/01/2024-03/31/2024)
• STAR@UTEP Program (NIH Jumpstart mentorship program) - ORSP, University of Texas at El Paso (01/01/2023-12/31/2023)
• VERITY/Brigham Course and Mentorship Program in Rheumatology Clinical Research Award - Brigham and Women's Hospital, Harvard Medical School (05/01/2022-05/31/2022)
• Open Access Author Fund Award - The University of Kansas Medical Center (01/01/2019-12/31/2019)
• KUMC SGC Travel Award - The University of Kansas Medical Center (01/01/2018-12/31/2018)
• Outstanding Graduate Teaching Assistant Award - The University of Kansas Medical Center (01/01/2018-12/31/2018)
• Ringle-Norton Health Professions Scholarship - The University of Kansas Medical Center (01/01/2016-12/31/2016)
• The UIC Department of PT Award - The University of Illinois at Chicago (01/01/2014-12/31/2014)
• The Van Doren Scholarship - The University of Illinois at Chicago (01/01/2014-12/31/2014)
• Director’s Award - Nishi-Fukuoka Hospital (01/01/2009-12/31/2009)

• Postdoctoral Fellow, Epidemiology, Boston University School of Medicine (2022)
• Ph D in Rehabilitation Science, The University of Kansas Medical Center (2019)
• MS in Rehabilitation Science, The University of Illinois at Chicago (2015)
• BS in Physical Therapy, National Hospital Organization Sendai Medical Center Rehabilitation School (2005)

• Opioid induced hyperalgesia in osteoarthritis with Dr Kosaku Aoyagi Joint Action: Osteoarthritis Research Society International (2023), Kosaku Aoyagi.
• Mediating Effect of Pain Sensitization on the Paradoxical Relation of Taking Opioids to Pain Severity in Knee Osteoarthritis: The Multicenter Osteoarthritis Study Arthritis Care & Research (2023), Kosaku Aoyagi.
• Roles of physical therapists in interdisciplinary teams for chronic pain management The Journal of Manual Physical Therapy (2023), Kosaku Aoyagi.
• Delayed timing of physical therapy initiation increases the risk of future opioid use in individuals with knee osteoarthritis: a real-world cohort study British Journal of Sports Medicine (2023), Kosaku Aoyagi.
• Post-surgical contributors to persistent knee pain following knee replacement: The Multicenter Osteoarthritis Study (MOST) Osteoarthritis and Cartilage Open (2023), Kosaku Aoyagi, Laura F. Law, Lisa Carlesso, Michael Nevitt, Cora E. Lewis, Na Wang, Tuhina Neogi.
• Does weight-bearing versus non-weight-bearing pain reflect different pain mechanisms in knee osteoarthritis?: the Multicenter Osteoarthritis Study (MOST) Osteoarthritis and Cartilage 30 4 (2022), Kosaku Aoyagi, J.W. Liew, J.T. Farrar, N. Wang, L. Carlesso, D. Kumar, L. Frey Law, C.E. Lewis, M. Nevitt, T. Neogi.
• Associations of Central Pain Sensitization with Wearable Sensor-Derived Gait Complexity and Dynamic Stability in Knee Osteoarthritis: The Multicenter Osteoarthritis Study IASP World Congress 2022 (2022), Torabian K., Neogi T., Wang N., Aoyagi K.,, Lee S., Stefanik J., Frey-Law L., Carlesso L.,, Hausdorff J., Gazit E., Segal N., Lewis C.,, Kumar. D. Nevitt M..
• Associations of Nociceptive Dysfunction with Physical Activity in Knee Osteoarthritis: The Multicenter Osteoarthritis Study American College of Rheumatology Convergence 2022 (2022), Kumar D., Wang N., Torabian K., Aoyagi K.,, Stefanik J., Frey-Law L., Carlesso L., Hausdorff J.,, Gazit E., Segal N., Lewis CE., Nevitt M.,, Neogi T..
• Longitudinal Trajectories of Central Pain Sensitization in People with or at Risk of Knee Osteoarthritis American College of Rheumatology (2022), Kosaku Aoyagi, Neogi T. Nevitt M..
• Relation of PainDETECT to Unpredictable Pain in People with or at Risk of Knee Osteoarthritis American College of Rheumatology Convergence 2022 (2022), Aoyagi K., Wang N., Frey-Law L., Rabasa G.,, Lewis CE., Nevitt M., Neogi T..
• Sleep quality in individuals with chronic low back pain and central sensitization Physiotherapy Research International (2022), Kosaku Aoyagi, Jianghua He, Daniel J. Clauw, Neena K. Sharma.
• Association of Physical Therapy Interventions With Long-term Opioid Use After Total Knee Replacement JAMA Network Open 4 10 (2021), Kosaku Aoyagi, Tuhina Neogi, Christine Peloquin, Maureen Dubreuil, Lee Marinko, James Camarinos, David T. Felson, Deepak Kumar.
• Relation of Depressive Symptoms to Alterations in Conditioned Pain Modulation in Knee Osteoarthritis: The Multicenter Osteoarthritis Study (MOST) ARTHRITIS & RHEUMATOLOGY 73 (2021), Kosaku Aoyagi, Lisa Carlesso, Laura Frey-Law, Gabriela Rabasa, Cora Lewis, Michael Nevitt, Tuhina Neogi.
• Correlation Between Central Sensitization and Remote Muscle Performance in Individuals With Chronic Low Back Pain. Journal of manipulative and physiological therapeutics 44 1 (2021), Kosaku Aoyagi, N K. Sharma.
• Protocol for Testing Yoga to Reduce Post–Lumbar Spine Surgery Pain: A Methodology Article International Journal of Yoga Therapy 31 1 (2021), Neena K. Sharma, Kosaku Aoyagi, Mary K. Crouch Young, Alyssa Parrish, Carol Smith, Douglas C. Burton, Paul M. Arnold, Kelly Colln, Yvonne Colgrove.
• Quantifying Lumbar Mobilization With Inertial Measurement Unit Journal of Manipulative and Physiological Therapeutics 43 2 (2020), Fahed Mehyar, Sara E. Wilson, Vincent S. Staggs, Kosaku Aoyagi, Neena K. Sharma.
• Association between Opioid Dose, Acute Post-operative Pain and Walking Distance Following Lumbar Spine Surgery. Journal of clinical pharmacy and therapeutics 45 1 (2020), Kosaku Aoyagi, J He, M Simpson, B L. Melton, S Chandaka, L R. Waitman, N K. Sharma.
• BILATERAL SENSORY DEFICITS AND WIDESPREAD HYPERALGESIA OCCUR FOLLOWING INDUCED DELAYED ONSET MUSCLE SORENESS OF THE QUADRICEPS. International journal of sports physical therapy 15 1 (2020), C A. Courtney, Kosaku Aoyagi, C Fernández-de-Las-Peñas, P Madeleine.
• Development of a Pain Sensitivity Index to Examine the Transition from Intermittent to Constant Pain in Knee Osteoarthritis: The Multicenter Osteoarthritis Study ARTHRITIS & RHEUMATOLOGY 72 (2020), Kosaku Aoyagi, Lisa Carlesso, S. R. Jafarzadeh, Michael LaValley, Na Wang, Laura F. Law, Beth Lewis, Michael Nevitt, Tuhina Neogi.
• Do Weight-bearing versus Non-weight-bearing Pain Reflect Different Pain Mechanisms in Knee Osteoarthritis?: The Multicenter Osteoarthritis Study ARTHRITIS & RHEUMATOLOGY 72 (2020), Jean Liew, John Farrar, Na Wang, Lisa Carlesso, Kosaku Aoyagi, Laura F. Law, Cora Lewis, Michael Nevitt, Tuhina Neogi.
• Relation of Pain Mechanisms to Development of Knee Pain in Osteoarthritis: The Multicenter Osteoarthritis Study ARTHRITIS & RHEUMATOLOGY 72 (2020), Tuhina Neogi, Na Wang, Kosaku Aoyagi, Laura F. Law, Cora Lewis, Michael Nevitt, Lisa Carlesso.
• A Subgroup of Chronic Low Back Pain Patients With Central Sensitization. The Clinical journal of pain 35 11 (2019), Kosaku Aoyagi, J He, A L. Nicol, D J. Clauw, P M. Kluding, S Jernigan, N K. Sharma.
• Is spinal mobilization effective for low back pain?: A systematic review Complementary Therapies in Clinical Practice 34 (2019), Kosaku Aoyagi, David Heller, David Hazlewood, Neena Sharma, Marcio dos Santos.

• Current assessment and treatment strategies for central pain mechanisms (2023), Kosaku Aoyagi.
• The Effect of Aerobic Exercise on Pressure Pain Thresholds in People with Chronic Low Back Pain (2023), Yoshiro Takano, Kosaku Aoyagi.
• Longitudinal Relation of Central Pain Sensitization to Development of Inefficient Descending Pain Inhibition in Knee Osteoarthritis: The Multicenter Osteoarthritis Study (2023), Kosaku Aoyagi, Lisa Carlesso, Na Wang, Laura Frey-Law, Cora Lewis, Michael Nevitt, Tuhina Neogi.
• Longitudinal Trajectories of Pain Sensitization in People with or at Risk of Knee Osteoarthritis (2023), Kosaku Aoyagi, Na Wang, Laura Frey-Law, Cora Lewis, Michael Nevitt, Tuhina Neogi.
• Associations of Nociceptive Dysfunction with Physical Activity in Knee Osteoarthritis: The Multicenter Osteoarthritis Study (2022), Kumar D., Wang N., Torabian K., Aoyagi K., Stefanik J., Frey-Law L., Carlesso L., Hausdorff J., Gazit E., Segal N., Lewis CE., Nevitt M., Neogi T.
• Longitudinal Trajectories of Central Pain Sensitization in People with or at Risk of Knee Osteoarthritis (2022), Aoyagi K., Wang N., Frey-Law L., Lewis CE., Nevitt M., Neogi T.
• Relation of PainDETECT to Unpredictable Pain in People with or at Risk of Knee Osteoarthritis (2022), Aoyagi K., Wang N., Frey-Law L., Rabasa G., Lewis CE., Nevitt M., Neogi T.
• Associations of Central Pain Sensitization with Wearable Sensor-Derived Gait Complexity and Dynamic Stability in Knee Osteoarthritis: The Multicenter Osteoarthritis Study (2022), Torabian K., Neogi T., Wang N., Aoyagi K., Lee S., Stefanik J., Frey-Law L., Carlesso L., Hausdorff J., Gazit E., Segal N., Lewis C., Nevitt M., Kumar. D. .
• Association of Conditioned Pain Modulation with Exercise-Induced Hypoalgesia in Knee Osteoarthritis (2022), Lee, S., T. Neogi, K. E. Costello, N. Shah, M. J. Rose, B. Friscia, Aoyagi K. Torabian, Kumar D.
• Longitudinal Relation of Central Pain Sensitization to Development of Inefficient Descending Pain Inhibition in Knee Osteoarthritis (2022), Aoyagi K., Carlesso L., Wang N., Frey-Law L., Lewis CE., Nevitt M., Neogi T.
• Association between Impaired Exercise Induced Hypoalgesia and Physical Activity in People with Knee Osteoarthritis (2022), Mehta A., Costello KE., Rose MJ., Lee S., Frey-Law L., Aoyagi K., Neogi T., Kumar D.

• I-REACH Rural Veterans