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• 2022: UTEP College of Science Outstanding Dissertation Faculty Research Mentoring - UTEP College of Science (05/01/2022)
• 2022: UTEP College of Science Outstanding Thesis Faculty Research Mentoring - UTEP College of Science (05/01/2022)
• 2019 NIH BUILDING Sumner sabbatical research award - NIH (04/01/2019)
• FASEB (Federation of American Societies for Experimental Biology) MARC Travel Award - NIH (05/01/2016-05/31/2016)

• Ph D in Physics, Huazhong University of Science and Technology (2011)
• BA in Physics, Huazhong University of Science and Technology (2005)

• Using machine learning method to study the kinesin Ncd binding with microtubule Biophysical Journal (2023), Wenhan Guo, Dan Du, Houfang Zhang, Jason Sanchez, Shengjie Sun, Wang Xu, Yunhui Peng, Lin Li.
• Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies. International Journal of Molecular Sciences (2023), Omar J. Rodriguez, Stephanie A. Chavez, Victor H. Estrada, Shengjie Sun, Lin Li, Robert A. Kirken, Georgialina Rodriguez.
• Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies. (2023), Omar J. Rodriguez, Stephanie A. Chavez, Victor H. Estrada, Shengjie Sun, Lin Li, Robert A. Kirken, Georgialina Rodriguez.
• JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation. International journal of molecular sciences 24 15 (2023), Georgialina Rodriguez, Gustavo Martinez, O D. Negrete, S Sun, W Guo, Yan Xie, Lin Li, Chuan Xiao, Jeremy Ross, Robert A. Kirken.
• JAK3 Y841 autophosphorylation is critical for kinase domain stability and dimer formation. International Journal of Molecular Sciences (2023), Omar J. Rodriguez Moncivais, George S. Martinez, Omar D. Negrete, Shengjie Sun, Wenhan Guo, Yixin Xie, Lin Li, Aleksander C. Lazarski, Chuan Xiao, Robert A. Kirken, Georgialina Rodriguez.
• Phosphorylation of Tyrosine 841 Plays a Significant Role in JAK3 Activation. (2023), Shengjie Sun, Georgialina Rodriguez, Yixin Xie, Wenhan Guo, Alan E. Lopez Hernandez, Jason E. Sanchez, Robert A. Kirken, Lin Li.
• Phosphorylation of Tyrosine 841 Plays a Significant Role in JAK3 Activation Life 13 4 (2023), Shengjie Sun, Georgialina Rodriguez, Yixin Xie, Wenhan Guo, Alan E. Lopez Hernandez, Jason E. Sanchez, Robert A. Kirken, Lin Li.
• Phosphorylation of Tyrosine 841 Plays a Significant Role in JAK3 Activation Life 13 4 (2023), Shengjie Sun, Georgialina Rodriguez, Yixin Xie, Wenhan Guo, Alan E. Lopez Hernandez, Jason E. Sanchez, Robert A. Kirken, Lin Li.
• JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling International Journal of Molecular Sciences 24 7 (2023), Alice H. Grant, Alejandro C. Rodriguez, Omar J. Rodriguez Moncivais, Shengjie Sun, Lin Li, Ming-Ying Leung, Robert A. Kirken, Georgialina Rodriguez.
• JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling International Journal of Molecular Sciences 24 7 (2023), Alice H. Grant, Alejandro C. Rodriguez, Omar J. Rodriguez Moncivais, Shengjie Sun, Lin Li, Ming-Ying Leung, Robert A. Kirken, Georgialina Rodriguez.
• JAK1 V666G Mutant Impairs IL-2 Signaling in Leukemia. (2023), Omar J. Rodriguez Moncivais, Alice H. Grant, Alejandro C. Rodriguez, Shengjie Sun, Lin Li, Jonathon E. Mohl, Ming-Ying Leung, Robert A. Kirken, Georgialina Rodriguez.
• JAK1 V666G Mutant Impairs IL-2 Signaling in Leukemia. (2023), Omar J. Rodriguez Moncivais, Alice H. Grant, Alejandro C. Rodriguez, Shengjie Sun, Lin Li, Jonathon E. Mohl, Ming-Ying Leung, Robert A. Kirken, Georgialina Rodriguez.
• Structural-Functional Analysis of JAK3 Y841 Phosphorylation. (2023), Stephanie A. Chavez, Omar J. Rodriguez Moncivais, George S. Martinez, Shengjie Sun, Wenhan Guo, Yixin Xie, Lin Li, Chuan Xiao, Robert A. Kirken, Georgialina Rodriguez.
• Structural-Functional Analysis of JAK3 Y841 Phosphorylation. (2023), Stephanie A. Chavez, Omar J. Rodriguez Moncivais, George S. Martinez, Shengjie Sun, Wenhan Guo, Yixin Xie, Lin Li, Chuan Xiao, Robert A. Kirken, Georgialina Rodriguez.
• A Comprehensive Study on the Electrostatic Properties of Tubulin-Tubulin Complexes in Microtubules Cells 12 (2023), Wenhan Guo, Tolulope Ale, Shengjie Sun, Jason Sanchez, Lin Li.
• JAK3 Y841 autophosphorylation is critical for kinase domain stability and dimer formation. (2023), Omar J. Rodriguez Moncivais, George S. Martinez, Omar D. Negrete, Shengjie Sun, Wenhan Guo, Yixin Xie, Lin Li, Aleksander C. Lazarski, Chuan Xiao, Robert A. Kirken, Georgialina Rodriguez.
• Nitrate-driven anaerobic oxidation of ethane and butane by bacteria The ISME Journal: Multidisciplinary Journal of Microbial Ecology 12 (2023), Mengxiong W. Guo, Jie Li, Chun-Yu Lai, Andy Leu, Shengjie Sun, Rui Gu, Dirk Erler, Lian Liu, Lin Li, Gene Tyson, Zhiguo Yuan, Simon Mcllroy, Jianhua G. .
• HIT-2: Implementing machine learning algorithms to treat bound ions in biomolecules Computational and Structural Biotechnology Journal 20 (2023), Shengjie Sun, Honglun Xu, Yixin Xie, Wenhan Guo, Jason Sanchez, Dongfang Liu, Lin Li.
• Electrostatics in Computational Biophysics and Its Implications for Disease Effects International Journal of Molecular Sciences (2022), Shengjie Sun, Emil Alexov, Lin Li.
• Using a comprehensive approach to investigate the interaction between Kinesin-5/Eg5 and the microtubule Computational and Structural Biotechnology Journal (2022), Wenhan Guo, Shengjie Sun, Jason Sanchez, Yixin Xie, Tolulope Ale, Weihong Qiu, Lin Li.
• Computational Study on E-Hooks of Tubulins in the Binding Process with Kinesin International journal of molecular sciences (2022), Yixin Xie, Lin Li.
• HIT web server: A hybrid method to improve electrostatic calculations for biomolecules Computational and Structural Biotechnology Journal 20 (2022), Shengjie Sun, Juan Lopez, Yixin Xie, Wenhan Guo, Dongfang Liu, Lin Li.
• Molecular mechanisms of cardiac actomyosin transforming from rigor state to post-rigor state The Journal of Chemical Physics (2022), Shengjie Sun, Chitra Karki, Bruce Z. Gao, Lin Li.
• DG-Labeler and DGL-MOTS Dataset: Boost the Autonomous Driving Perception (2022), Yiming Cui, Zhiwen Cao, Yixin Xie, Xingyu Jiang, Feng Tao, Yingjie V. Chen, Lin Li, Dongfang Liu.
• Computational Study on the Function of Palmitoylation on the Envelope Protein in SARS-CoV-2 Journal of Chemical Theory and Computation 17 10 (2021), Shengjie Sun, Chitra Karki, Javier Aguilera, Alan E. Lopez Hernandez, Jianjun Sun, Lin Li.
• Computational Study on the Function of Palmitoylation on the Envelope Protein in SARS-CoV-2 Journal of Chemical Theory and Computation (2021), Shengjie Sun, Chitra Karki, Javier Aguilera, Alan E. Lopez Hernandez, Jianjun Sun, Lin Li.
• Computational saturation mutagenesis of SARS-CoV-1 spike glycoprotein: stability, binding affinity, and comparison with SARS-CoV-2 Frontiers in Molecular Biosciences (2021), Adebiyi Sobitan, Vidhyanand Mahase, Raina Rhoades, Dejaun Williams, Dongxiao Liu, Yixin Xie, Lin Li, Qiyi Tang, Shaolei Teng.
• Computational Study on DNA Repair: The Roles of Electrostatic Interactions between Uracil-DNA Glycosylase (UDG) and DNA Frontiers in Molecular Biosciences 8 (2021), Yixin Xie, Chitra B. Karki, Jiawei Chen, Dongfang Liu, Lin Li.
• Electrostatic features for nucleocapsid proteins of SARS-CoV and SARS-CoV-2 Mathematical Biosciences and Engineering 18 3 (2021), Wenhan Guo, Yixin Xie, Alan E. Lopez-Hernandez, Shengjie Sun, Lin Li.
• Hybrid method for representing ions in implicit solvation calculations Computational and Structural Biotechnology Journal (2021), Shengjie Sun, Chitra Karki, Yixin Xie, Yuejiao Xian, Wenhan Guo, Bruce Z. Gao, Lin Li.
• The electrostatic features of dengue virus capsid assembly Journal of Computational Biophysics and Chemistry 20 2 (2021), Alan E. Lopez-Hernandez, Yixin Xie, Wenhan Guo, Lin Li.
• A computational model of ESAT-6 complex in membrane Journal of Theoretical and Computational Chemistry (2020), Chitra Karki, Yuejiao Xian, Yixin Xie, Shengjie Sun, Alan E. Lopez-Hernandez, Brenda Juarez, Jun Wang, Jianjun Sun, Lin Li.
• Nα-Acetylation of the virulence factor EsxA is required for mycobacterial cytosolic translocation and virulence Journal of Biological Chemistry 295 17 (2020), Javier Aguilera, Chitra B. Karki, Lin Li, Salvador Vazquez Reyes, Igor Estevao, Brian I. Grajeda, Qi Zhang, Chenoa D. Arico, Hugues Ouellet, Jianjun Sun.
• Nα-Acetylation of the virulence factor EsxA is required for mycobacterial cytosolic translocation and virulence Journal of Biological Chemistry 295 17 (2020), Javier Aguliera, Chitra Karki, Lin Li, Salvador Vasquez-Reyes, Igor Estavo, Brian Grajeda, Qi Zhang, Chenoa D. Arico, Hugues Ouellet, Jianjun Sun.
• Computational analysis of hereditary spastic paraplegia mutations in the kinesin motor domains of KIF1A and KIF5A Journal of Theoretical and Computational Chemistry 19 06 (2020), Vidhyanand Mahase, Adebiyi Sobitan, Christina Johnson, Farion Cooper, Yixin Xie, Lin Li, Shaolei Teng.
• Electrostatics of Prokaryotic Ribosome and Its Biological Implication Biophysical Journal (2020), Jun Wang, Chitra Karki, Yi Xiao, Lin Li.
• N$\alpha$-Acetylation of the virulence factor EsxA is required for mycobacterial cytosolic translocation and virulence Journal of Biological Chemistry 295 17 (2020), Javier Aguilera, Chitra B. Karki, Lin Li, Salvador V. Reyes, Igor Estevao, Brian I. Grajeda, Qi Zhang, Chenoa D. Arico, Hugues Ouellet, Jianjun Sun.
• Revealing the mechanism of SARS-CoV-2 spike protein binding with ACE2 Computing in Science \& Engineering (2020), Yixin Xie, Dan Du, Chitra Karki, Wenhan Guo, Alan Lopez-Hernandez, Shengjie Sun, Brenda Juarez, Haotian Li, Jun Wang, Lin Li.
• Special Issue on Novel Methods in Computational Chemistry and their Applications to Biological Problems: Part 2 World Scientific (2020), Lin Li.
• Spike proteins of SARS-CoV and SARS-CoV-2 utilize different mechanisms to bind with human ACE2 Frontiers in molecular biosciences 7 (2020), Yixin Xie, Chitra B. Karki, Dan Du, Haotian Li, Jun Wang, Adebiyi Sobitan, Shaolei Teng, Qiyi Tang, Lin Li.
• Structure Manipulation Tool StructureMan: A Structure Manipulation tool to study large scale biomolecular interactions Frontiers in Molecular Biosciences 7 (2020), Yuejiao Xian, Yixin Xie, Sebastian M. Silva, Chitra Karki, Weihong Qiu, Lin Li.
• The Roles of Electrostatic Interactions in Capsid Assembly Mechanisms of Giant Viruses International journal of molecular sciences 20 8 (2019), Yuejiao Xian, Chitra B. Karki, Sebastian M. Silva, Lin Li, Chuan Xiao.
• DelPhi Suite: New Developments and Review of Functionalities Journal of Computational Chemistry (2019), Chuan Li, Zhe Jia, Arghya Chakravorty, Swagata Pahari, Yunhui Peng, Sankar Basu, Mahesh Koirala, Shailesh K. Panday, Marharyta Petukh, Lin Li, others.
• DFMD: Fast and effective DelPhiForce steered molecular dynamics approach to model ligand approach toward a receptor: Application to spermine synthase enzyme Frontiers in molecular biosciences 6 (2019), Yunhui Peng, Ye Yang, Lin Li, Zhe Jia, Weiguo Cao, Emil Alexov.
• The Roles of Electrostatic Interactions in Capsid Assembly Mechanisms of Giant Viruses International journal of molecular sciences 20 8 (2019), Yuejiao Xian, Chitra B. Karki, Sebastian M. Silva, Lin Li, Chuan Xiao.
• Using computational approaches to study dengue virus capsid assembly Comput. Math. Biophys. 7 (2019), Gicela Saucedo Salas, Alan E Lopez Hernandez, Jiadi He,, Chitra Karki, Yixin Xie, Shengjie Sun, Yuejiao Xian,, Lin Li*.

• Using hybrid solvent model to explore the bound ions effects (2023), Volume Austin, TX, Wenhan Guo, Lin Li.
• Developing computational approaches to study biomolecule interactions (2023), Volume Riverside, CA, Lin Li.
• Computational Study On Microtubule: Electrostatic Interactions Play Essential Roles In Microtubule Dynamics (2023), Volume San Diego, CA, Wenhan Guo, Lin Li.
• Using a Comprehensive Approach to Study the Mechanisms of Eg5 and Microtubule (2022), Volume Washington, DC, Wenhan Guo, Jason Sanchez, Lin Li.
• Developing and utilizing computational physics approaches to study biology problems (2022), Volume Corvallis, OR, Lin Li.
• Using computational approaches to reveal mechanisms of kinesin-5 binding with microtubule (2022), Volume Austin, TX, Wenhan Guo, Jason Sanchez, Lin Li.
• Using computational approach to reveal the mechanisms of viral capsid assembly (2022), Volume San Diego, CA, Lin Li.
• Developing and applying computational approach to investigate the viral structures (2021), Volume Online, Lin Li.
• Using computational approaches to reveal mechanisms of molecular motors’ motility (2021), Lin Li.
• Developing and utilizing a multiscale computational approach to study molecular motors’ motility (2021), Volume Tucson, AZ, Lin Li.
• Developing multi-scale computational approaches to study molecular motors (2021), Volume University of Texas at Permian Basin, Odessa, TX, Lin Li.
• Revealing the mechanisms of molecular motors’ motility by using computational approaches (2021), Volume Online, Lin Li.
• Revealing the mechanisms of viral capsid assembly using computational approaches (2021), Volume Atlanta, GA, Lin Li.
• Developing and applying computational physics methods to understand molecular motors’ motility (2021), Volume online, Lin Li.
• Using computational biophysics approach to study virtual capsid assembly (2020), Volume Clemson University, Clemson, SC., Lin Li.
• Develop multiscale computational method for molecular motors (2019), Volume Bethesda, MD, Lin Li.
• Using computational approaches to reveal mechanisms of molecular motors (2019), Volume Washington DC, Lin Li.
• The roles of electrostatic interactions in capsid assembly mechanisms of giant icosahedral viruses (2019), Volume Ringberg Castle, Tegernsee, Germany, Yuejiao Xian, Chitra B. Karki, Sebastian M. Silva, Lin Li, Chuan Xiao.
• Using computational approach to study molecular motors (2019), Volume Washington DC, Lin Li.
• Protein-protein interactions: understanding the mechanisms of viral capsids assembly (2019), Volume El Paso, TX, Lin Li.
• Reveal the essential role of protein-protein interactions in viral capsid assembly (2019), Volume San Diego, CA, Lin Li.
• Electrostatics-driven capsid assembly and disassembly of giant viruses (2019), Volume Minneapolis, MN, USA, Yuejaio Xian, Chitra B. Karki, Sebastian M. Silva, Lin Li, Chuan Xiao.
• The roles of electrostatic interactions in capsid assembly mechanisms of giant viruses (2019), Volume Brainerd, MN, USA, Yuejiao Xian, Chitra B. Karki, Sebastian M. Silva, Lin Li, Chuan Xiao.
• Using multi-scale approach to reveal mechanisms of molecular motors’ motility (2019), Volume Albuquerque, NM, Lin Li.

• Developing and applying multi-scale simulation approach to understand the mechanisms of kinesins' directional motions along microtubules
• Deciphering the Molecular Assembly Mechanism of Giant DNA Viruses (re-submission)
• BUILDing SCHOLARS Summer Sabbatical Program
• STRUCTURE-FUNCTION RELATIONSHIP OF NOVEL PHOSPHOREGULATORY SITES AND EFFECT OF ACUTE LYMPHOBLASTIC LEUKEMIA SNPS ON JAK3 ACTIVITY: IMPLICATIONS FOR NEW CANCER TREATMENTS
• Using novel simulation method to study the mechanism of molecular motor’s motility
• BBRC Supported research to identify novel druggable targets in Jak3 as cancer therapeutics
• MSEIP Supplemental Funding: Research Capacity
• UTEP startup grant